[Studies on the differentiation of chondrocytes in connection with poly ADP ribose synthesis]

Cell differentiation and the behaviour of poly-(ADP-ribose)-synthesis after treatment with methoxybenzamide and procaine was examined in chondrocytes of cell cultures from albino rats. In this study an increase in cell differentiation was connected with a higher level of poly(ADP-ribose)-synthesis. On the basis of an increase in poly(ADP-ribose)-synthesis in chondrocytes an improved scheme of treatment of some rheumatic diseases could be developed.