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  11. Prostate-specific Membrane Antigen-targeted Surgery In Prostate Cancer: Accurate Identification, Real-time Diagnosis, And Precise Resection

Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection

Jianhua Jiao1,2, Jingjing Zhang3,4,5,6, Weihong Wen7

  • 1Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

Theranostics
|May 22, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

PSMA-targeted surgery enhances prostate cancer treatment by improving accuracy in diagnosis and resection. This approach offers a more precise method for surgeons, potentially benefiting both primary and recurrent cases.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Surgical Oncology

Background:

  • Radical prostatectomy (RP) with pelvic lymph node dissection (PLND) is standard for localized prostate cancer (PCa).
  • Traditional surgical extent relies heavily on surgeon experience and preoperative imaging.
  • Limitations exist in precisely identifying and resecting all cancerous tissue and lymph nodes.

Purpose of the Study:

  • To review the advancements and applications of prostate-specific membrane antigen (PSMA)-targeted surgical techniques in prostate cancer.
  • To evaluate the potential of PSMA-targeted surgery in improving pathological diagnosis and surgical outcomes.
  • To discuss the benefits and limitations of various PSMA-guided surgical modalities.

Main Methods:

  • Review of literature on PSMA-targeted surgical interventions for prostate cancer.
Keywords:
image-guided surgeryintraoperativemolecular imagingprostate cancer

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  • Inclusion of techniques such as PSMA-PET-guided biopsy (PSMA-TB), PSMA-targeted radio-guided surgery (PSMA-RGS), and PSMA-targeted fluorescence-guided surgery (PSMA-FGS).
  • Analysis of multi-modality and multi-targeted PSMA-guided approaches.

    • Main Results:

    • PSMA-targeted surgery offers enhanced precision for pathological diagnosis and complete resection of positive surgical margins (PSMs).
    • These techniques aid in the detection and removal of micro-lymph node metastases (LNMs).
    • Various PSMA-guided methods show promise in improving surgical accuracy and convenience.

    Conclusions:

    • PSMA-targeted surgery represents a significant advancement in prostate cancer management.
    • It has the potential to improve the accuracy and convenience of surgical interventions for both primary and recurrent PCa.
    • Further integration into existing surgical protocols is recommended for enhanced patient outcomes.
    prostate-specific membrane antigen (PSMA)