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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Mitochondria01:37

Mitochondria

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Updated: Jun 25, 2025

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Addressing the Missing Links in Cardiovascular Aging.

Elliot Dinetz1, Claudia Zeballos-Palacios2, Claudia A Martinez3

  • 1Department of Integrative and Family Medicine, University of Miami Miller School of Medicine Miami, Miami, FL, USA.

Clinical Interventions in Aging
|May 22, 2024
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Summary

This review explores enhancing cardiovascular health in aging populations by examining the gut microbiome, environmental toxins, and hormone replacement. A comprehensive systems-biology approach can improve risk assessment and disease prevention.

Keywords:
bioidentical hormone replacementcardiovascular aginginflammagingmicrobiomesystems biology medicinetoxic metalsvascular aging

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Area of Science:

  • Cardiovascular Health and Aging
  • Systems Biology
  • Preventive Medicine

Background:

  • Cardiovascular disease (CVD) poses a significant threat to the aging population.
  • Current strategies for CVD prevention in older adults require enhancement.
  • A systems-biology perspective offers novel insights into cardiovascular aging.

Purpose of the Study:

  • To review strategies for improving cardiovascular health in aging individuals.
  • To explore a systems-biology approach for CVD prevention in the elderly.
  • To identify key factors influencing cardiovascular aging.

Main Methods:

  • Literature review of existing research on cardiovascular aging.
  • Analysis of the role of the gut microbiome in cardiovascular health.
  • Evaluation of environmental toxin impact on aging cardiovascular systems.
  • Assessment of age-related sex hormones and supplement replacement therapies.

Main Results:

  • The gut microbiome, environmental toxins, and sex hormones significantly influence cardiovascular aging.
  • A comprehensive approach integrating these factors can enhance cardiovascular health.
  • Early identification and intervention are crucial for CVD prevention in older adults.

Conclusions:

  • Integrating gut microbiome, toxin removal, and hormone management offers a promising strategy for cardiovascular health in aging.
  • This systems-biology approach facilitates earlier risk assessment and disease prevention.
  • Further research is needed to refine therapeutic interventions for healthier cardiovascular aging.