Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Histology of the Small Intestine01:27

Histology of the Small Intestine

724
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
724
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimal Timing of Resuming Anticoagulant After Colorectal Endoscopic Submucosal Dissection.

Journal of gastroenterology and hepatology·2026
Same author

High detection rates and associated factors of colorectal serrated lesions: a multicenter prospective study in the Asia-Pacific.

The American journal of gastroenterology·2026
Same author

Non-injection resection using bipolar soft coagulation mode for large colorectal polyps including incidental cancer.

Endoscopy·2025
Same author

Ergonomic endoscopy: Path to your sustainable endoscopy practice.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2025
Same author

Use of a short educational video to improve the accuracy of colorectal polyp morphology assessment: A multicenter randomized controlled study.

DEN open·2025
Same author

Surveillance after Endoscopic Resection for Colorectal Tumors: A Comprehensive Review.

Digestion·2024

Related Experiment Video

Updated: Jun 25, 2025

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol
10:54

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol

Published on: April 4, 2018

15.3K

A diminutive perivascular epithelioid cell tumor in the colon.

Naoki Sugimura1, Daizen Hirata1, Mineo Iwatate1

  • 1Gastrointestinal Center & Institute of Minimally-Invasive Endoscopic Care (i-MEC) Sano Hospital Hyogo Japan.

DEN Open
|May 22, 2024
PubMed
Summary
This summary is machine-generated.

This study reports the smallest colorectal angiomyolipoma, a rare perivascular epithelioid cell tumor (PEComa), successfully resected via colonoscopy. The findings offer crucial insights into the early morphology of these rapidly progressing tumors.

Keywords:
PEComaangiomyolipomacolondiminutivemesenchymal tumor

More Related Videos

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.4K
In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

35.1K

Related Experiment Videos

Last Updated: Jun 25, 2025

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol
10:54

Isolation of Human Endothelial Cells from Normal Colon and Colorectal Carcinoma - An Improved Protocol

Published on: April 4, 2018

15.3K
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.4K
In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

35.1K

Area of Science:

  • Gastroenterology and Oncology
  • Pathology

Background:

  • Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms.
  • Morphological variations in PEComas correlate with disease progression, impacting treatment strategies.
  • Early-stage colorectal PEComa morphology remains poorly understood, complicating timely diagnosis and intervention.

Observation:

  • A 64-year-old male patient presented with a 4-mm pale blue, elevated, non-pedunculated lesion in the transverse colon during a follow-up colonoscopy.
  • Initial suspicion was a submucosal tumor due to lack of epithelial changes.
  • The lesion was successfully resected using cold snare polypectomy.

Findings:

  • Histological examination revealed a submucosal tumor with thickened vascular walls, adipose tissue, and spindle-shaped cells positive for smooth muscle actin.
  • The tumor exhibited calcifications and hyalinized tissue, consistent with angiomyolipoma, a subtype of PEComa.
  • This represents the smallest reported colorectal PEComa, confirmed as angiomyolipoma.

Implications:

  • Early detection and endoscopic resection of small colorectal PEComas are feasible.
  • Understanding the morphology of early-stage PEComas can guide diagnostic and therapeutic approaches.
  • This case expands the understanding of PEComa presentation and highlights the importance of thorough histopathological evaluation.