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Ethical frameworks of informed consent in the age of pediatric precision medicine

David Chen1,2

  • 1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Cambridge Prisms. Precision Medicine
|May 22, 2024
PubMed

Insights

In pediatric precision medicine, ethical informed consent is crucial for patient autonomy. This primer reviews current frameworks and modern adaptations to improve consent processes for children.

Area of Science:

  • Biomedical Ethics
  • Pediatric Precision Medicine
  • Health Law and Policy

Background:

  • Precision medicine utilizes patient-specific data for targeted therapies.
  • Informed consent is a cornerstone of patient autonomy in medical decision-making.
  • Pediatric consent practices face challenges due to evolving guidelines and patient vulnerability.

Purpose of the Study:

  • To provide a clinical primer on ethical informed consent frameworks in pediatrics.
  • To explore modern adaptations for improving informed consent in pediatric precision medicine.
  • To address the implementation of consent in pediatric precision medicine workflows.

Main Methods:

  • Review of established ethical informed consent frameworks.
  • Analysis of current guidelines for pediatric consent.
  • Discussion of emerging adaptations for precision medicine contexts.

Main Results:

  • Existing frameworks require adaptation for pediatric precision medicine.
  • Modern approaches emphasize enhanced communication and patient engagement.
  • Interdisciplinary collaboration is key for effective consent processes.

Conclusions:

  • Optimizing informed consent in pediatric precision medicine necessitates updated ethical frameworks.
  • Building trust and rapport with pediatric patients and families is essential.
  • Clinical implementation requires integration with interdisciplinary health teams.

Keywords:
assentconsentethicspediatricprecision medicine

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