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Congenital Hyperlipidemia in Infants for Congenital Cardiac Surgery

Madhu A Yadav1, Dipesh Trivedi2, Hriday Chandra3

  • 1Department of Anaesthesia and Critical Care Division, Sri Padmavathi Children's Heart Centre, Tirupathi, Andhra Pradesh, India.

JACC. Case Reports
|May 22, 2024
PubMed

Insights

Severe hypertriglyceridemia in infants with complex congenital heart disease poses significant surgical risks. This case series details managing these risks during critical heart surgeries.

Area of Science:

  • Pediatric Cardiology
  • Cardiothoracic Surgery
  • Metabolic Disorders

Background:

  • Infants with complex congenital heart disease (CHD) often require surgical intervention.
  • Severe hypertriglyceridemia is a rare but critical comorbidity in these infants.
  • Perioperative management in this population presents unique challenges.

Observation:

  • This case series describes two infants with concurrent severe hypertriglyceridemia and complex CHD.
  • Both infants underwent major cardiac surgeries: total anomalous pulmonary venous connection repair and ventricular septal defect closure.
  • The study focuses on the perioperative course and management strategies.

Findings:

  • Severe hypertriglyceridemia significantly complicates surgical outcomes in infants with complex CHD.
  • Effective management strategies are crucial for mitigating perioperative risks.
  • Troubleshooting metabolic derangements is key to successful surgical intervention.

Implications:

  • Highlights the need for multidisciplinary care teams for infants with hypertriglyceridemia and CHD.
  • Informs surgical planning and anesthetic management for similar high-risk cases.
  • Suggests potential areas for further research into managing hypertriglyceridemia during pediatric cardiac surgery.

Keywords:
cardiopulmonary bypasscongenital heart diseaseinfantlipoprotein lipase deficiencypediatric cardiac surgerysevere hypertriglyceridemia

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