Renal metastasis from esophageal adenocarcinoma: A rare recurrence

Esophageal cancer, consisting primarily of squamous cell carcinoma and adenocarcinoma pathology, is a leading cause of morbidity and mortality worldwide with rates of metastasis at time of diagnosis up to 50%. Renal metastasis is rare, with most pathological diagnosis yielding squamous cell carcinoma. We present the unique case of a 78-year-old man with biopsy proven adenocarcinoma metastasis to the kidney on routine surveillance following initial esophagectomy, chemoradiation and adjuvant immunotherapy. Imaging features of the solitary renal metastasis highly mimicked a primary renal cell carcinoma. Additional unique features included renal pelvis invasion and disease recurrence despite adjuvant immunotherapy. This case underscores the role of routine surveillance in this patient population, varied radiologic appearance, and importance for pathologic diagnosis.