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The relationship between Mycoplasma and Kawasaki disease in pediatric patients: An updated systematic review and

Min Cheng1, Gaihuan Zheng2, Lu Gao1

  • 1Department of Pediatrics, Chongqing Medical University, Chongqing, China.

Archives of Rheumatology
|May 22, 2024
PubMed
Abstract

Insights

Mycoplasma pneumoniae infection is common in children with Kawasaki disease. Further research is needed to understand the lower hemoglobin and erythrocyte sedimentation rate in these patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Rheumatology
  • Microbiology

Background:

  • Kawasaki disease is an acute febrile illness affecting young children.
  • The etiology of Kawasaki disease remains unclear, with infectious agents being investigated.
  • Mycoplasma pneumoniae has been implicated as a potential trigger.

Purpose of the Study:

  • To systematically review and meta-analyze existing studies on the association between Mycoplasma pneumoniae and Kawasaki disease.
  • To determine the pooled prevalence of M. pneumoniae infection in pediatric patients diagnosed with Kawasaki disease.
  • To analyze clinical parameters in Kawasaki disease patients with and without M. pneumoniae infection.

Main Methods:

  • Systematic review and meta-analysis of studies published before October 2022.
  • Inclusion of six studies comprising 1,859 pediatric patients with Kawasaki disease.
  • Calculation of pooled prevalence using a random effects model and analysis of clinical parameters like hemoglobin and erythrocyte sedimentation rate.

Main Results:

  • A statistically significant pooled prevalence of Mycoplasma pneumoniae infection was found in pediatric patients with Kawasaki disease.
  • Significant differences in hemoglobin and erythrocyte sedimentation rate were observed between M. pneumoniae-infected and non-infected Kawasaki disease patients.
  • No significant differences were noted in other clinical parameters between the two groups.

Conclusions:

  • Mycoplasma pneumoniae infection is significantly prevalent in pediatric patients diagnosed with Kawasaki disease.
  • Lower hemoglobin and erythrocyte sedimentation rate values in M. pneumoniae-infected Kawasaki disease patients warrant further investigation.
  • The findings suggest a potential role for M. pneumoniae in the pathogenesis of Kawasaki disease.
Keywords:
Erythrocyte sedimentation rateKawasaki diseasehemoglobinmeta-analysismycoplasmapooled prevalence.

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