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PI3K/AKT Signaling Pathway Mediated Autophagy in Oral Carcinoma - A Comprehensive Review

Peramaiyan Rajendran1,2, Ramya Sekar3,2, Prabhu Shankar Dhayasankar4

  • 1Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.

International Journal of Medical Sciences
|May 22, 2024
PubMed

Insights

This review explores the PI3K/AKT/mTOR pathway

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Signaling

Background:

  • Oral cancer exhibits significant clinical and histological heterogeneity.
  • The PI3K/AKT/mTOR pathway is frequently dysregulated in oral cancer, controlling vital cellular functions.
  • Targeting this pathway offers potential for developing specific oral cancer therapeutics with reduced toxicity.

Purpose of the Study:

  • To elucidate the regulation of the PI3K/AKT/mTOR pathway in oral squamous cell carcinoma (OSCC).
  • To detail the pathway's role in regulating autophagy and apoptosis during OSCC progression and metastasis.
  • To identify upstream activators and downstream effectors of PI3K/AKT/mTOR signaling as therapeutic targets for oral cancer.

Main Methods:

  • Literature review focusing on PI3K/AKT/mTOR signaling in oral cancer.
  • Analysis of studies investigating pathway regulation, autophagy, and apoptosis.
  • Identification of potential therapeutic targets within the PI3K/AKT/mTOR pathway.

Main Results:

  • The PI3K/AKT/mTOR pathway is a key regulator of cellular and metabolic activities in oral cancer.
  • Dysregulation of this pathway influences autophagy and apoptosis, contributing to OSCC progression and metastasis.
  • Specific proteins within the pathway present viable targets for novel oral cancer drug development.

Conclusions:

  • The PI3K/AKT/mTOR pathway is a critical determinant in oral squamous cell carcinoma.
  • Understanding its regulatory mechanisms and downstream effects is crucial for effective oral cancer treatment strategies.
  • Targeting components of the PI3K/AKT/mTOR pathway holds promise for improving oral cancer therapy.
Keywords:
PI3K/AKTautophagymetastasisoral cancer

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