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The Network between Heart and Liver from the View of Persian Medicine Versus Conventional Medicine
Azadeh Zarei1, Mehrdad Karimi1, Hossein Rezaeizadeh1
1Department of Traditional Persian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Insights
Network medicine reveals that Persian medicine
Area of Science:
- Integrative medicine
- Network medicine
- Cardiology
- Hepatology
Background:
- The heart and liver are vital organs with interconnected functions and common metabolic pathways.
- Disruptions in one organ can impact the other, leading to systemic diseases.
- Network medicine offers a framework to map these complex interdependencies.
Purpose of the Study:
- To explore the relationship between heart and liver diseases using a network medicine approach.
- To compare the perspectives of conventional and Persian medicine on heart-liver connections.
- To identify shared etiological factors between cardiac and hepatic conditions.
Main Methods:
- Systematic review of conventional medicine literature on heart-liver relationships.
- Analysis of Persian medicine texts for disease causation.
- Network analysis using RStudio to visualize heart-liver connections based on Persian medicine principles.
Main Results:
- Persian medicine's focus on material causes aligns with conventional medicine's understanding of shared genes, metabolites, and pathways between heart and liver.
- Network analysis confirmed compatibility between traditional and modern medical viewpoints.
- Identified commonalities in disease etiology across different medical systems.
Conclusions:
- Understanding the interconnectedness of heart and liver diseases aids in predicting co-occurrence.
- This integrated approach can improve diagnostic accuracy and therapeutic strategies.
- Network medicine provides a valuable tool for bridging conventional and traditional medical knowledge.
Background:
Liver and heart are two important organs in the human body, whose function strongly affects other organs. On the other hand, these two main organs affect each other due to common metabolic pathways. Therefore, a disorder in any of them can lead to disease in other organs. Today, using the network medicine perspective, these complex connections can be easily mapped and discovered. From the Persian medicine viewpoint, links are formed based on the material causes of diseases, while from the conventional medicine viewpoint, they are mostly formed due to metabolites, genes, and pathways.
Materials And Methods:
In this article, we first investigated the recent articles of conventional medicine that examine the relationship between heart and liver in the important databases. Then, we checked out the sources of Persian medicine and finally, using the RStudio software used in network medicine for text mining, we drew the communication network centered on heart and liver and their mutual causes from the perspective of Persian Medicine.
Results:
Examining the network connection between the heart and the liver showed that the definitions based on Persian medicine, which are based on the material causes of diseases, are very compatible with the genes, metabolites and pathways between these two organs.
Conclusion:
Understanding these concepts can be helpful in detecting the co-occurrence of diseases of these two organs, as well as predicting the possible occurrence of related diseases between the heart and liver, and ultimately in better treatment.
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