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Polycythemia Vera Masked by Megaloblastic Anemia
M Loukhnati1, K Khalil1, F E Lahlimi1
1Department of Hematology and Bone Marrow Transplantation Mohammed VI University Hospital, Cadi Ayyad University, 40080 Marrakesh, Morocco.
The Gulf Journal of Oncology
|May 22, 2024
Summary
Polycythemia vera (PV) can present with megaloblastic anemia due to Vitamin B12 deficiency. This case report details an atypical PV presentation, highlighting diagnostic complexities.
Area of Science:
- Hematology
- Internal Medicine
Background:
- Polycythemia vera (PV) is a myeloproliferative disorder causing excess red blood cell production.
- Megaloblastic anemia results from cobalamin (vitamin B12) and/or folate (vitamin B9) deficiency.
Observation:
- A case of an 85-year-old North African woman with PV and concurrent Vitamin B12 deficiency megaloblastic anemia is presented.
- This presentation is atypical and not fully understood in its physiopathology.
Findings:
- The co-occurrence of megaloblastic anemia and PV in this patient underscores a complex clinical scenario.
- Diagnostic delays and treatment complexities arise from this unusual association.
Implications:
- This case highlights the importance of considering Vitamin B12 deficiency in patients with Polycythemia vera.
- Further research into the physiopathology of this association may improve diagnostic and therapeutic strategies for PV patients.
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