Association between recent exposure to continuous glucose monitoring-recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Recent exposure to hypoglycemia, detected by continuous glucose monitoring (CGM), blunts the adrenaline response in people with type 1 diabetes. This indicates impaired counterregulation following prior low blood glucose events.
Area Of Science
- Endocrinology
- Metabolic Disorders
- Diabetes Research
Background
- Experimental hypoglycemia impairs counterregulatory hormone and symptom responses to subsequent hypoglycemia.
- Understanding the impact of recent hypoglycemia exposure on these responses is crucial for managing type 1 diabetes.
Purpose Of The Study
- To assess the association between antecedent continuous glucose monitoring (CGM)-recorded hypoglycemia over one week and counterregulatory responses to experimental hypoglycemia in type 1 diabetes.
- Investigate the impact of prior hypoglycemia exposure on hormonal and symptomatic reactions to induced hypoglycemia.
Main Methods
- Forty-two individuals with type 1 diabetes underwent a one-week CGM monitoring period.
- A standardized hyperinsulinemic-hypoglycemic clamp was performed to induce hypoglycemia (2.8 ± 0.1 mmol/L).
- Counterregulatory hormone levels and symptom responses were measured during the clamp.
Main Results
- CGM-recorded hypoglycemia in the preceding week was negatively associated with adrenaline response (p=0.014), particularly level 2 hypoglycemia (<3.0 mmol/L).
- Hypoglycemia exposure was also linked to reduced autonomic and neuroglycopenic symptom responses, though these associations diminished after confounder adjustment.
- Adrenaline response attenuation was independently associated with recent CGM-detected hypoglycemia.
Conclusions
- Recent exposure to hypoglycemia, as detected by CGM, is independently linked to an attenuated adrenaline response during experimental hypoglycemia in type 1 diabetes patients.
- This finding highlights the potential for impaired counterregulation following recent low blood glucose events.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...