Attitudes, Beliefs, and Intention to Receive a COVID-19 Vaccine for Pediatric Patients With Sickle Cell Disease

Area of Science:

• Public Health
• Hematology
• Infectious Diseases

Background:

• Sickle Cell Disease (SCD) is a significant risk factor for severe COVID-19 outcomes, particularly in individuals of African descent.
• Black communities exhibit higher COVID-19 vaccine hesitancy and lower vaccination rates, necessitating targeted research.
• Understanding vaccine intention predictors is crucial for improving vaccination behaviors in at-risk populations.

Purpose of the Study:

• To examine attitudes, beliefs, and intentions regarding COVID-19 vaccines among adolescents, young adults, and caregivers of children with SCD.
• To identify key predictors of COVID-19 vaccine intention within the SCD population.
• To explore educational preferences for vaccine information among SCD patients and their caregivers.

Main Methods:

• A multisite online survey was conducted between July 2021 and March 2022.
• Multivariate logistic regression analyzed associations between participant age, COVID-19 vaccine attitudes, beliefs, and intentions.
• Data were collected from 200 participants, including adolescents, young adults, and caregivers of children with SCD.

Main Results:

• COVID-19 vaccine intention was reported by 65.1% of adolescents, 62.5% of young adults, and 48.4% of caregivers.
• Perception of vaccine safety was a significant predictor of intention to vaccinate for both patients and caregivers.
• Participant age was significantly associated with the intention to receive a COVID-19 booster vaccine.

Conclusions:

• Perceived vaccine safety is a critical factor influencing COVID-19 vaccine intention in the SCD community.
• Age is a significant factor in booster vaccine intent among individuals with SCD.
• Findings underscore the need for tailored educational strategies and messaging campaigns to address concerns and promote COVID-19 vaccination within the pediatric SCD population.