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Updated: Jun 25, 2025

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
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Toward Multiscale, Multimaterial 3D Printing.

Cheng Zhu1, Hawi B Gemeda1, Eric B Duoss1

  • 1Center for Engineered Materials and Manufacturing, Materials Engineering Division, Lawrence Livermore National Laboratory, 7000 East Ave, Livermore, CA, 94550, USA.

Advanced Materials (Deerfield Beach, Fla.)
|May 22, 2024
PubMed
Summary
This summary is machine-generated.

3D printing enables the creation of advanced materials by mimicking biological self-organization. This review explores techniques for multiscale and multimaterial 3D printing, addressing current challenges and future potential.

Keywords:
energy depositionmaterial extrusionmultimaterial 3D printingmultiscale 3D printingphotopolymerization

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Area of Science:

  • Materials Science
  • Biomimetics
  • Additive Manufacturing

Background:

  • Biological systems exhibit inherent self-organization, creating complex hierarchical structures with advanced properties.
  • Material scientists are inspired by these natural composites to develop novel engineered materials.
  • Additive manufacturing (3D printing) offers a powerful platform for fabricating intricate multiscale and multimaterial structures.

Purpose of the Study:

  • To review 3D printing techniques capable of producing multiscale and multimaterial structures.
  • To highlight innovations in printing methods, material processing, and hardware for advanced additive manufacturing.
  • To discuss current challenges and future perspectives in achieving combined multiscale and multimaterial 3D printing.

Main Methods:

  • Review of existing literature on additive manufacturing for multiscale and multimaterial fabrication.
  • Analysis of key features in printing methods, material processing, and hardware innovations.
  • Discussion of challenges and future research directions.

Main Results:

  • Identification of key 3D printing techniques for multiscale and multimaterial fabrication.
  • Overview of advancements in material processing and hardware for complex structures.
  • Discussion of limitations and potential solutions for current methods.

Conclusions:

  • 3D printing holds significant potential for creating advanced multifunctional materials by integrating multiscale and multimaterial capabilities.
  • Further research is needed to overcome current challenges and fully realize the potential of these techniques.
  • The integration of multiscale and multimaterial approaches in 3D printing is crucial for future material innovation.