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Reversing Metabolic Dysfunction-Associated Steatotic Liver Disease Promotes Healthy Pediatric Cardiovascular

Menglong Li1, Wen Shu1, Yuchen Zou1

  • 1Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.

The American Journal of Gastroenterology
|May 22, 2024
PubMed

Insights

Controlling metabolic dysfunction-associated steatotic liver disease (MASLD) in children is linked to better cardiovascular health. Children who normalized MASLD showed reduced carotid intima-media thickness and left ventricular mass.

Area of Science:

  • Pediatrics
  • Cardiology
  • Hepatology

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in children.
  • The impact of MASLD on pediatric cardiovascular development requires further investigation.

Purpose of the Study:

  • To investigate the association between MASLD and cardiovascular structure development in a pediatric cohort.
  • To assess if MASLD control influences cardiovascular outcomes in children.

Main Methods:

  • A longitudinal study followed 1,356 children (mean age 6.6 years) in Beijing for 4.5 years.
  • Cardiovascular structure was assessed using carotid intima-media thickness and left ventricular mass.
  • MASLD status was monitored, categorizing children into persistent MASLD, incident MASLD, and MASLD normalization groups.

Main Results:

  • Children with MASLD normalization exhibited significantly lower carotid intima-media thickness (0.161 vs. 0.188 mm) compared to those with persistent MASLD.
  • Left ventricular mass was also significantly lower in children with MASLD normalization (4.5 vs. 12.4 g) than in those with persistent MASLD.
  • A total of 59 children had persistent MASLD, 109 had incident MASLD, and 35 achieved MASLD normalization.

Conclusions:

  • Control and normalization of MASLD in children are associated with improved cardiovascular structure development.
  • These findings highlight the importance of managing MASLD in pediatric populations to mitigate cardiovascular risks.
Abstract

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