Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA studies in brucellar spondylitis.

G S Alarcón, E Gotuzzo, S A Hinostroza

    Clinical Rheumatology
    |September 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Limit of detection of <i>Salmonella</i> ser. Enteritidis using culture-based versus culture-independent diagnostic approaches.

    Microbiology spectrum·2024
    Same author

    Factors associated with screening failure and study withdrawal in multidrug-resistant TB.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2022
    Same author

    [Encuesta epidemiologica sobre algunas enfermedades viricas en los bovinos de la Provincia de Corrientes, Argentina].

    Revue scientifique et technique (International Office of Epizootics)·2020
    Same author

    Structural Glycoprotein E2 of Classical Swine Fever Virus Interacts with Host Protein Dynactin Subunit 6 (DCTN6) during the Virus Infectious Cycle.

    Journal of virology·2019
    Same author

    Delimitation of the upstream region of NFKBIA gene associated with HTLV-1-associated myelopathy/tropical spastic paraparesis using candidate Tag-SNPs in Peruvian HTLV-1 infected individuals.

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2019
    Same author

    HIV-related tuberculosis: mortality risk in persons without vs. with culture-confirmed disease.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2019

    This study investigated if HLA antigens B27 and B7-CREG predispose Peruvian patients to brucellar spondylitis. No association was found, suggesting other genetic factors may be involved in brucellosis arthritis.

    Area of Science:

    • Infectious Diseases
    • Immunogenetics
    • Rheumatology

    Background:

    • Brucellosis frequently causes arthritis, with both infectious and reactive articular syndromes recognized.
    • Human Leukocyte Antigen (HLA) B27 and B7-Common Region (CREG) antigens are associated with various spondyloarthropathies.
    • The role of these antigens in brucellar spondylitis remains unclear.

    Purpose of the Study:

    • To investigate the association between HLA B27 and B7-CREG antigens and the occurrence of brucellar spondylitis in mestizo Peruvian patients.

    Main Methods:

    • A case-control study was conducted.
    • Fourteen mestizo Peruvian patients with brucellar spondylitis were analyzed.
    • HLA B27 and B7-CREG antigen typing was performed.

    Related Experiment Videos

    Main Results:

    • No significant association was found between HLA B27 or B7-CREG antigens and brucellar spondylitis in the studied population.
    • The frequency of B27 and B7-CREG antigens in the control population was low.

    Conclusions:

    • HLA B27 and B7-CREG antigens do not appear to be predisposing factors for brucellar spondylitis in this Peruvian cohort.
    • The possibility of a 'native' antigen contributing to susceptibility requires further investigation.