Electrochemical Sensor for the Detection and Accurate Early Diagnosis of Ovarian Cancer

Feng Ge ¹, Wei Ding ², Cong Han ³

⁰Clinical School of Obstetrics and Gynecology Center, Tianjin Medical University, Tianjin 301700, China.

Acs Sensors +

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May 22, 2024

View abstract on PubMed

Summary

This study presents a novel electrochemical sensor for early ovarian cancer (OC) detection using exosomes. The developed platform accurately identifies cancer-derived exosomes, offering a promising tool for noninvasive diagnosis.

Area Of Science

Biomedical Engineering
Oncology
Nanotechnology

Background

Ovarian cancer (OC) exhibits high mortality due to challenges in early diagnosis.
Exosomes, as cell-derived vesicles, are crucial in OC progression and metastasis.
Exosomes show potential as noninvasive biomarkers for early cancer detection.

Purpose Of The Study

To develop a novel sensor for accurate and early diagnosis of ovarian cancer.
To identify cancer-derived exosomes as a biomarker for early OC detection.
To create a universal platform for differentiating ovarian cancer subtypes.

Main Methods

Fabrication of a metal-organic frameworks assembled "double hook"-type aptamer electrochemical sensor.
Utilized electrochemical impedance spectroscopy for exosome detection and quantification.
Validated the platform's ability to differentiate between high-grade serous OC, non-HGSOC, and healthy individuals.

Main Results

The sensor demonstrated a good linear relationship (31–3.1 × 10^6 particles/µL) with a low detection limit (12 particles/µL).
The platform successfully distinguished between high-grade serous ovarian cancer (HGSOC) patients and healthy controls.
The sensor effectively differentiated HGSOC from non-HGSOC patients, indicating diagnostic potential.

Conclusions

The developed electrochemical sensor offers a sensitive and specific method for early OC detection.
This platform represents a significant advancement in the clinical differential diagnosis of ovarian cancer.
The exosome-based detection strategy holds promise for noninvasive early diagnosis and personalized treatment approaches.

Keywords:

aptamers early diagnosis electrochemical sensor exosomes ovarian cancer