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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
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Related Experiment Video

Updated: Jun 25, 2025

Bioluminescent Bacterial Imaging In Vivo
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Sono-activatable engineered bacteria for antitumor therapy.

Yuanyuan Wang1, Fei Yan1

  • 1CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Cell Reports. Medicine
|May 22, 2024
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Summary
This summary is machine-generated.

Engineered bacteria offer new tumor treatment options. Researchers developed ultrasound-controlled bacteria to safely deliver therapeutic agents directly to tumors, enhancing treatment efficacy and safety.

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Area of Science:

  • Biotechnology
  • Oncology
  • Microbiology

Background:

  • Bacteria present a promising avenue for cancer therapy due to their ability to selectively colonize tumor microenvironments.
  • However, safety concerns and uncontrolled bacterial activity hinder their clinical translation.

Purpose of the Study:

  • To engineer bacteria for controlled therapeutic cargo delivery in tumors.
  • To enhance the safety and efficacy of bacterial tumor treatment using external control mechanisms.

Main Methods:

  • Development of sono-activatable gene circuits integrated into engineered bacteria.
  • Utilizing ultrasound to trigger local production and release of therapeutic agents within the tumor.
  • In vivo testing of ultrasound-controlled bacterial therapy.

Main Results:

  • Successful engineering of bacteria with ultrasound-responsive gene circuits.
  • Demonstrated localized production and release of therapeutic cargos upon ultrasound stimulation.
  • Evidence of enhanced therapeutic effect and improved safety profile in preclinical models.

Conclusions:

  • Ultrasound-controlled engineered bacteria represent a significant advancement in targeted cancer therapy.
  • This approach offers a safer and more effective method for utilizing bacteria in tumor treatment.
  • Sono-activatable gene circuits provide precise spatial and temporal control over bacterial therapeutic functions.