Prioritizing of potential environmental exposure carcinogens beyond IARC group 1-2B based on weight of evidence (WoE) approach
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View abstract on PubMed
Summary
This summary is machine-generated.Identifying potential carcinogens is crucial for safety. This study introduces a novel weight of evidence (WoE) approach using computational methods to prioritize environmental exposures, successfully identifying new and known cancer-causing chemicals.
Area Of Science
- Environmental Health
- Toxicology
- Computational Chemistry
Background
- Environmental exposures are a primary cause of cancer.
- The carcinogenicity of many environmental substances remains unevaluated.
- Prioritizing potential carcinogens is essential for public health and safety.
Purpose Of The Study
- To develop and evaluate a novel weight of evidence (WoE) approach for prioritizing environmental carcinogens.
- To integrate various computational methods for enhanced carcinogen identification.
- To identify previously unevaluated environmental exposures with high carcinogenic concern.
Main Methods
- Development and evaluation of four distinct weight of evidence (WoE) approaches.
- Integration of computational toxicology methods: read-across, structural alerts, (Quantitative) Structure-Activity Relationship ((Q)SAR), and chemical-disease association.
- Application of the WoE approach to 681 environmental exposures not classified by IARC groups 1-2B.
Main Results
- The proposed WoE-1 approach demonstrated significant improvements in predictive performance (AUC +0.21, MCC +0.39) compared to single computational methods.
- The study prioritized 52 chemicals of high carcinogenic concern from the evaluated environmental exposures.
- Eight compounds were identified as potential carcinogens for the first time, alongside 21 known or suspected carcinogens.
Conclusions
- The weight of evidence (WoE) approach effectively integrates diverse computational methods for robust carcinogen prioritization.
- This novel approach successfully identifies and prioritizes environmental exposures with significant carcinogenic potential.
- The findings provide a critical tool for enhancing safety assessments of environmental chemicals and informing public health strategies.
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