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Updated: Aug 16, 2026

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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
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Intracranial CAR-T cell delivery in glioblastoma patients
Philippa Vaughn-Beaucaire1, Moon Jung Choi2, Olin Liang2
1Department of Pathology and Laboratory Medicine, Legoretta Cancer Center, Brown University, Providence, RI 02903, USA.
Trends in Cancer
|May 22, 2024
Abstract:
Chimeric antigen receptor (CAR)-T cell therapy is emerging as a promising approach for improving outcomes in high-grade glioma. Here, we highlight three recent studies that reported safety and feasibility of intracranial CAR-T cell administration in patients with glioblastoma (GBM) as well as preliminary evidence of potential responses, supporting further investigations of this approach.

