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Updated: Jun 25, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery
Ivan V Zelepukin1,2, Konstantin G Shevchenko3, Sergey M Deyev4
1Department of Medicinal Chemistry, Uppsala University, 751 23, Uppsala, Sweden. ivan.zelepukin@ilk.uu.se.
Abstract:
Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier - the approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis of the published data we prove the efficacy of this technique for enhancing particle circulation in blood and their delivery to tumours, describe a century of its evolution and potential combined mechanism behind it. Finally, we discuss future directions of the research focusing on the features essential for successful clinical translation of the method.
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