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Updated: Jun 25, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
Competing endogenous RNA networks and ferroptosis in cancer: novel therapeutic targets
Fatemeh Nejadi Orang1, Mahdi Abdoli Shadbad2,3
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
As a newly identified regulated cell death, ferroptosis is a metabolically driven process that relies on iron and is associated with polyunsaturated fatty acyl peroxidation, elevated levels of reactive oxygen species (ROS), and mitochondrial damage. This distinct regulated cell death is dysregulated in various cancers; activating ferroptosis in malignant cells increases cancer immunotherapy and chemoradiotherapy responses across different malignancies. Over the last decade, accumulating research has provided evidence of cross-talk between non-coding RNAs (ncRNAs) and competing endogenous RNA (ceRNA) networks and highlighted their significance in developing and progressing malignancies. Aside from pharmaceutical agents to regulate ferroptosis, recent studies have shed light on the potential of restoring dysregulated ferroptosis-related ceRNA networks in cancer treatment. The present study provides a comprehensive and up-to-date review of the ferroptosis significance, ferroptosis pathways, the role of ferroptosis in cancer immunotherapy and chemoradiotherapy, ceRNA biogenesis, and ferroptosis-regulating ceRNA networks in different cancers. The provided insights can offer the authorship with state-of-the-art findings and future perspectives regarding the ferroptosis and ferroptosis-related ceRNA networks and their implication in the treatment and determining the prognosis of affected patients.
Insights
Ferroptosis, a regulated cell death process, shows promise in cancer treatment by enhancing immunotherapy and chemoradiotherapy responses. Restoring ferroptosis-related competing RNA networks offers new therapeutic strategies for various cancers.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Ferroptosis is a regulated cell death pathway dependent on iron and lipid peroxidation, implicated in cancer progression.
- Dysregulation of ferroptosis impacts cancer development and response to therapies like immunotherapy and chemoradiotherapy.
- Non-coding RNAs (ncRNAs) and competing endogenous RNA (ceRNA) networks play crucial roles in cancer, with emerging links to ferroptosis.
Purpose of the Study:
- To provide a comprehensive review of ferroptosis, its pathways, and its role in cancer treatment.
- To explore the significance of ferroptosis-regulating ceRNA networks in various malignancies.
- To highlight the therapeutic potential of targeting ferroptosis and ceRNA networks in cancer.
Main Methods:
- Literature review of ferroptosis mechanisms and cancer research.
- Analysis of the interplay between ncRNAs, ceRNAs, and ferroptosis pathways.
- Synthesis of current findings on ferroptosis-modulating ceRNA networks in cancer.
Main Results:
- Ferroptosis activation enhances responses to cancer immunotherapy and chemoradiotherapy.
- Dysregulated ferroptosis-related ceRNA networks are observed across different cancer types.
- Targeting these networks presents a novel therapeutic avenue.
Conclusions:
- Ferroptosis is a critical process in cancer, influencing treatment efficacy.
- Ferroptosis-regulating ceRNA networks are key players in cancer pathogenesis and progression.
- Restoring these networks offers promising future strategies for cancer therapy and prognosis.
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