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Updated: Jun 25, 2025

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
Published on: January 6, 2010
Controlled oxygen delivery to power tissue regeneration
Elizabeth Zoneff1,2, Yi Wang1,2, Colin Jackson3,4
1The Graeme Clark Institute, The University of Melbourne, Parkville, Melbourne, VIC, Australia.
Abstract:
Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen delivery systems. To become a reality, these systems must consider physiological processes, oxygen release mechanisms and the target application. In this review, we explore the biological relevance of oxygen at both a cellular and tissue level, and the importance of its controlled delivery via engineered biomaterials and devices. Recent advances and upcoming trends in the field are also discussed with a focus on tissue-engineered constructs that could meet metabolic demands to facilitate regeneration.
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