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Updated: Jun 25, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating

Rui Shi1, Rong Zhao1, Yan Shen2

  • 1Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, PR China.

Cancer Gene Therapy
|May 22, 2024
PubMed

Insights

This study reveals a new circular RNA, circCHD7, promotes endometrial cancer (EC) by stabilizing PDGFRB mRNA via m6A modification. This discovery offers a potential therapeutic target for EC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • RNA Biology

Background:

  • Circular RNAs (circRNAs) are implicated in cancer progression.
  • N6-methyladenosine (m6A) methylation is a key RNA modification in cancer.
  • The roles of m6A and circRNAs in endometrial cancer (EC) are not fully understood.

Purpose of the Study:

  • To investigate the role of m6A-modified circRNAs in endometrial cancer progression.
  • To identify and characterize a novel circRNA involved in EC.

Main Methods:

  • Identification of differentially expressed circRNAs in EC tissues.
  • Functional assays to assess the impact of circCHD7 on EC cell proliferation.
  • Mechanistic studies involving RNA immunoprecipitation and Western blotting to explore molecular interactions and signaling pathways.

Main Results:

  • A novel m6A-modified circRNA, hsa_circ_0084582 (circCHD7), was upregulated in EC tissues and promoted EC cell proliferation.
  • circCHD7 enhances the stability of PDGFRB mRNA in an m6A-dependent manner by interacting with IGF2BP2.
  • The circCHD7/IGF2BP2/PDGFRB axis activates the JAK/STAT signaling pathway, driving EC cell proliferation.

Conclusions:

  • circCHD7 acts as an oncogenic circRNA in endometrial cancer through the m6A-dependent regulation of PDGFRB.
  • The identified circCHD7/IGF2BP2/PDGFRB axis provides novel insights into EC pathogenesis.
  • circCHD7 represents a potential therapeutic target for endometrial cancer.

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