Polygenic risk score predicting susceptibility and outcome of benign prostatic hyperplasia in the Han Chinese

Sheng-Chun Hung^1,2,3, Li-Wen Chang^1,2,3, Tzu-Hung Hsiao^4,5,6

¹Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.

Human Genomics

|May 22, 2024

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View abstract on PubMed

Summary

A higher polygenic risk score (PRS) is linked to increased benign prostatic hyperplasia (BPH) risk and poorer treatment outcomes in Han Chinese men. This PRS may help identify individuals needing earlier intervention for BPH.

Area of Science:

Genetics and Urology
Personalized Medicine

Background:

Benign prostatic hyperplasia (BPH) significantly affects elderly men.
Early risk identification is crucial for effective BPH management.

Purpose of the Study:

To evaluate the predictive value of polygenic risk score (PRS) for BPH incidence.
To assess PRS in relation to BPH prognosis and surgical risk in Han Chinese.

Main Methods:

Retrospective cohort study of 12,474 Han Chinese men (TPMI).
PRS calculated using 1,712 SNPs (PGS001865).
Logistic regression analyzed PRS association with BPH, adjusting for age and PSA; examined PRS and TURP risk.

Main Results:

Highest PRS quartile showed significantly higher BPH risk (OR=1.51).
Higher PRS correlated with larger prostate volumes and reduced 5ARI treatment response.
Elevated PRS was an independent risk factor for transurethral resection of the prostate (TURP).

Conclusions:

Higher PRS is associated with increased BPH susceptibility and poorer outcomes in Han Chinese.
PRS predicts larger prostate size, reduced 5ARI efficacy, and higher TURP risk.
Further validation in larger, prospective studies is recommended.

Keywords:

5-α-reductase inhibitor Benign prostatic hyperplasia Incidence Polygenic risk score Prognosis Prostate-specific antigen level

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