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Bisphenol A release from CAD/CAM splint materials.

Tristan Hampe1, Julia Liersch1, Bernhard Wiechens1,2

  • 1Department of Prosthodontics, University Medical Center Göttingen, Göttingen, Germany.

European Journal of Oral Sciences
|May 23, 2024
PubMed
Summary
This summary is machine-generated.

Bisphenol A (BPA) release from CAD/CAM splint materials was investigated. All tested materials released significant BPA, with concentrations exceeding the European Union

Keywords:
dental materialsendocrine disruptorpolycarbonatepolymethylmethacrylate

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Dental Materials

Background:

  • Bisphenol A (BPA) is a chemical compound used in various plastic and resin materials.
  • Concerns exist regarding BPA leaching from dental materials into the oral environment.
  • Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) is increasingly used for fabricating dental splints.

Purpose of the Study:

  • To quantify and compare bisphenol A (BPA) release from four different CAD/CAM splint materials.
  • To assess whether BPA elution from these materials exceeds established safety thresholds.

Main Methods:

  • Four CAD/CAM splint materials (3 polycarbonate-based, 1 polymethylmethacrylate-based) were tested.
  • Cylindrical samples were immersed in HPLC-grade water and incubated at 37°C for 24 hours.
  • BPA concentration was analyzed using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Main Results:

  • All tested CAD/CAM splint materials released significant amounts of BPA.
  • BPA elution varied by material, with polycarbonate-based materials showing higher release than polymethylmethacrylate-based.
  • Calculated BPA concentrations per splint volume exceeded the European Union's Tolerable Daily Intake (TDI) by 1.32 to 6.16 times.

Conclusions:

  • CAD/CAM splint materials can be a significant source of BPA exposure in dental practice.
  • The high BPA elution levels warrant further investigation into material safety and potential health implications.
  • Material selection and clinical handling may influence BPA release from CAD/CAM splints.