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Updated: Jun 25, 2025
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05:15
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
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Organoselenium Compounds in Medicinal Chemistry.
Carola Gallo-Rodriguez1,2, Juan B Rodriguez1,3,2
1Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA, Buenos Aires, Argentina.
Chemmedchem
|May 23, 2024
Summary
Selenium, once a toxin, is now recognized as a vital trace element in medicine. Organoselenium compounds offer enhanced antioxidant and bioavailability properties for drug development.
Area of Science:
- Medicinal Chemistry
- Biochemistry
- Pharmacology
Background:
- Selenium's role has shifted from toxin to essential trace element.
- It is incorporated into selenoproteins (selenocysteine, selenocystine) crucial for biological reactions.
- Organoselenium compounds are explored as alternatives to sulfur/oxygen-based drugs.
Purpose of the Study:
- To review the application of selenium in medicinal chemistry.
- To highlight recent advances in pharmacological organoselenium compounds.
- To discuss the benefits of selenium in drug development.
Main Methods:
- Literature review focusing on recent publications (last few years).
- Analysis of pharmacological data for organoselenium compounds.
- Comparison of organoselenium drugs with existing sulfur and oxygen analogs.
Main Results:
- Organoselenium drugs exhibit potent antioxidant properties.
- Increased lipophilicity of organoselenium compounds enhances cell membrane permeation and oral bioavailability.
- Selenium's unique properties offer advantages over sulfur and oxygen in drug design.
Conclusions:
- Selenium is a valuable element in medicinal chemistry with significant therapeutic potential.
- Organoselenium compounds represent a promising class of drugs with improved pharmacokinetic profiles.
- Further research into organoselenium compounds is warranted for novel drug discovery.
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