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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

[Clinical study on the treatment of traumatic osteomyelitis of the upper tibia by membrane-induced technique combined with gastrocnemius muscle flap transposition].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2025
Same author

Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3<sup>+</sup>CD25<sup>+</sup>CD4<sup>+</sup> Treg cells via the IL-2/STAT5 signaling pathway.

Chinese journal of natural medicines·2022
Same author

PPAR-γ agonist pioglitazone alleviates inflammatory response induced by lipopolysaccharides in osteoblast cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2022
Same author

[Surgical treatment of traumatic osteomyelitis of extremities with MRSA infection].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2021
Same author

[Progress on complications of chronic osteomyelitis with bone defect treated by bone transportation].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2020
Same author

[Transfer of gastrocnemius muscle flap for postoperative infection with patellar internal fixation].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2018

Related Experiment Video

Updated: May 6, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis
09:20

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

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[Transcriptomic characteristics analysis of bone from chronic osteomyelitis].

Yang Zhang1, Yi-Yang Liu2, Li-Feng Shen3

  • 1Institute of Orthopaedics and Traumatology, the First Affliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou 310053, Zhejiang, China.

Zhongguo Gu Shang = China Journal of Orthopaedics and Traumatology
|May 23, 2024
PubMed
Summary

This study reveals the mitogen-activated protein kinase (MAPK) signaling pathway and osteoclast differentiation are key in chronic osteomyelitis. Genes like MAP3K7 and NFATC1 show promise as new therapeutic targets for this bone infection.

Area of Science:

  • Molecular biology
  • Genomics
  • Pathogenesis of infectious diseases
Keywords:
Chronic osteomyelitisMAPK pathwayOsteoclast differentiation pathwayTranscriptomics

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