Gastric cancer immune microenvironment score predicts neoadjuvant chemotherapy efficacy and prognosis
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View abstract on PubMed
Summary
This summary is machine-generated.Tumor-infiltrating immune cells predict neoadjuvant chemotherapy (NACT) response in advanced gastric cancer (GC). An immune microenvironment score (ISGC) effectively predicts NACT efficacy and patient survival, guiding personalized immunotherapy strategies.
Area Of Science
- Oncology
- Immunology
- Cancer Research
Background
- Neoadjuvant chemotherapy (NACT) efficacy in advanced gastric cancer (GC) is highly variable.
- Understanding the tumor immune microenvironment (TIME) is crucial for predicting treatment response and patient outcomes.
Purpose Of The Study
- To evaluate the predictive value of tumor-infiltrating immune cells (TIICs) for NACT response and prognosis in advanced GC.
- To investigate the impact of NACT on the TIME in GC patients.
- To develop an immune microenvironment score for GC (ISGC) to predict NACT efficacy.
Main Methods
- Paired tumor tissues (pre- and post-NACT) from advanced GC patients were analyzed.
- Immunohistochemistry was used to assess TIICs.
- Logistic regression and Kaplan-Meier curves were employed to develop the ISGC score and evaluate survival outcomes.
Main Results
- The TIME showed significant heterogeneity between NACT responders and non-responders.
- The ISGC score demonstrated strong predictive performance for NACT response and long-term survival.
- NACT altered TIIC populations, increasing T cells (CD3+, CD8+) and CD11c+ macrophages while decreasing CD163+ macrophages and FOXP3+ Treg cells in responders.
- Programmed cell death ligand 1 (PD-L1) expression increased post-NACT, particularly in responders.
Conclusions
- The ISGC model accurately predicts NACT efficacy and patient survival in advanced GC.
- NACT modulates the TIME in GC, suggesting potential for personalized immunotherapy approaches.
- TIIC profiling offers a valuable strategy for optimizing NACT and immunotherapy in gastric cancer.
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