[Multi-omics research progress in early-onset colorectal cancer]

Area of Science:

• Oncology
• Genomics
• Molecular Biology

Background:

• Early-onset colorectal cancer (EOCRC) incidence is increasing globally in individuals under 50.
• EOCRC presents distinct clinical, pathological, and molecular characteristics compared to late-onset colorectal cancer.
• EOCRC development is a complex, multi-factorial process influenced by environmental, genetic, and biological factors.

Purpose of the Study:

• To review research progress on early-onset colorectal cancer (EOCRC) utilizing multi-omics approaches.
• To provide a theoretical foundation for earlier diagnosis and more precise treatment strategies for EOCRC.
• To highlight the role of multi-omics in understanding complex disease pathogenesis.

Main Methods:

• Review of current scientific literature on early-onset colorectal cancer (EOCRC).
• Analysis of research applying multi-omics technologies (genomics, transcriptomics, proteomics, etc.).
• Synthesis of findings related to the pathogenesis and molecular features of EOCRC.

Main Results:

• Multi-omics analysis is crucial for dissecting the complex etiology of early-onset colorectal cancer (EOCRC).
• Distinct molecular profiles differentiate EOCRC from late-onset colorectal cancer.
• High-throughput sequencing and multi-omics data are advancing the understanding of EOCRC.

Conclusions:

• Multi-omics research is essential for unraveling the pathogenesis of early-onset colorectal cancer (EOCRC).
• These insights can pave the way for improved diagnostic tools and personalized therapies for EOCRC.
• Further multi-omics studies are needed to fully elucidate EOCRC mechanisms.