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Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
Published on: December 21, 2014
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Fibrinogen and tumors
Xinyuan Wu1,2, Xiaomin Yu2, Cheng Chen3
1School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Frontiers in Oncology
|May 23, 2024
Summary
Elevated fibrinogen (Fg) levels are linked to poor cancer prognosis. This review details how Fg in the tumor microenvironment drives inflammation, immune cell recruitment, and tumor progression, migration, and angiogenesis.
Area of Science:
- Oncology
- Biochemistry
- Immunology
Background:
- Elevated plasma fibrinogen (Fg) correlates with poor prognosis in cancer patients.
- Aberrant Fg deposition and expression occur within the tumor microenvironment.
- Fg interacts with cellular receptors, regulating inflammatory processes.
Purpose of the Study:
- To comprehensively review the role of fibrinogen in tumor biology.
- To elucidate the multifaceted mechanisms by which Fg influences cancer progression.
- To summarize recent findings on Fg-related signaling pathways in tumors.
Main Methods:
- Literature review of studies on fibrinogen and cancer.
- Analysis of Fg's interactions with cellular receptors and signaling pathways.
- Synthesis of data on Fg's effects on inflammation, immunity, angiogenesis, and migration.
Main Results:
- Fg stimulates and recruits immune cells and pro-inflammatory cytokines, promoting tumor progression.
- Fg and its fragments have dual effects on tumor angiogenesis.
- Fg facilitates tumor cell migration via platelet-dependent and -independent pathways.
Conclusions:
- Fibrinogen plays a complex and significant role in multiple aspects of tumor biology.
- Understanding Fg's mechanisms offers potential therapeutic targets for cancer treatment.
- Fg's involvement in inflammation, angiogenesis, and metastasis highlights its importance in cancer progression.
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