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Updated: Jun 25, 2025
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
410
Gastric Ulcer With Yttrium-90 Microsphere Selective Internal Radiation Therapy
Muhammad Mushtaq1, Rawan Dayah1, Brooke Corning1
1Department of Internal Medicine, University of Texas Medical Branch, Galveston, USA.
Cureus
|May 23, 2024
Summary
Radioembolization with yttrium-90 (Y90) can cause rare upper gastrointestinal bleeding due to gastric ulceration. This complication, confirmed by histology, differs from typical ulcers and may lead to serious issues.
Area of Science:
- Oncological interventional radiology
- Hepatobiliary and gastrointestinal complications
Background:
- Radioembolization with yttrium-90 (Y90) selective internal radiation therapy (Y90-SIRT) is an established treatment for liver cancers.
- While generally safe, Y90-SIRT has been associated with hepatic and extrahepatic complications.
Observation:
- A case of upper gastrointestinal bleeding was observed in a patient undergoing Y90-SIRT.
- The bleeding was attributed to gastric ulceration, confirmed via histological examination.
Findings:
- Radioembolization-induced gastric ulcers differ from common dyspeptic ulcers.
- These ulcers originate on the serosal surface, increasing risks of adhesions, obstruction, perforation, and bleeding.
Implications:
- Awareness of this specific ulcer type is crucial for managing Y90-SIRT complications.
- Early recognition and management can mitigate risks of severe gastrointestinal events.
- Further research into the pathogenesis and prevention of these ulcers is warranted.
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