Related Experiment Video

Updated: Jun 25, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

272

LncRNA TINCR: An Irreplaceable Biological Target in Human Malignancies

Dengke Jia1, Yaping He2, Yawu Zhang1,3,4

  • 1Lanzhou University Second Clinical Medical College, Lanzhou University, Lanzhou, 730000, China

Current Medicinal Chemistry
|May 23, 2024
PubMed

Insights

Terminal differentiation-induced ncRNA (TINCR) plays a key role in digestive system cancers. This review summarizes TINCR's molecular mechanisms and potential as a novel diagnostic marker for these malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Digestive system malignancies increasingly affect younger populations, posing a global health burden.
  • Long non-coding RNAs (lncRNAs) are crucial for tumor diagnosis and treatment.
  • Terminal differentiation-induced ncRNA (TINCR) has emerged as a significant factor in targeted cancer therapy, particularly for digestive system tumors.

Purpose of the Study:

  • To review and summarize the molecular mechanisms of TINCR in digestive system malignancies.
  • To highlight the potential of TINCR as a diagnostic biomarker.

Main Methods:

  • Systematic literature search on PubMed for studies on TINCR and digestive system malignancies.

Main Results:

  • TINCR exhibits bidirectional expression in digestive system malignant tumors.
  • TINCR primarily functions as a competing endogenous RNA (ceRNA) in these tumors.
  • TINCR also exerts regulatory functions at the transcriptional level.

Conclusions:

  • lncRNA TINCR demonstrates potential as a novel biomarker for digestive system cancers.
  • Understanding TINCR's mechanisms can inform targeted therapeutic strategies.
Keywords:
LncRNATINCRbiomolecular markerdiagnosisdigestive systemmalignant tumormetabolismtherapeutic target

More Related Videos

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

8.9K
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.3K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K