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LncRNA TINCR: An Irreplaceable Biological Target in Human Malignancies
Dengke Jia1, Yaping He2, Yawu Zhang1,3,4
1Lanzhou University Second Clinical Medical College, Lanzhou University, Lanzhou, 730000, China
Current Medicinal Chemistry
|May 23, 2024
Summary
Terminal differentiation-induced ncRNA (TINCR) plays a key role in digestive system cancers. This review summarizes TINCR's molecular mechanisms and potential as a novel diagnostic marker for these malignancies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Digestive system malignancies increasingly affect younger populations, posing a global health burden.
- Long non-coding RNAs (lncRNAs) are crucial for tumor diagnosis and treatment.
- Terminal differentiation-induced ncRNA (TINCR) has emerged as a significant factor in targeted cancer therapy, particularly for digestive system tumors.
Purpose of the Study:
- To review and summarize the molecular mechanisms of TINCR in digestive system malignancies.
- To highlight the potential of TINCR as a diagnostic biomarker.
Main Methods:
- Systematic literature search on PubMed for studies on TINCR and digestive system malignancies.
Main Results:
- TINCR exhibits bidirectional expression in digestive system malignant tumors.
- TINCR primarily functions as a competing endogenous RNA (ceRNA) in these tumors.
- TINCR also exerts regulatory functions at the transcriptional level.
Conclusions:
- lncRNA TINCR demonstrates potential as a novel biomarker for digestive system cancers.
- Understanding TINCR's mechanisms can inform targeted therapeutic strategies.
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