New materials and complications of prostheses in humans: situation in Spain

M Vallet-Regí , A De Alarcón , E Gómez Barrena

⁰Emilio Bouza, Servicio de Microbiología Clínica y Enfermedades Infecciosas del Hospital General Universitario Gregorio Marañón, Universidad Complutense. CIBERES. Ciber de Enfermedades Respiratorias. Madrid. Spain. emilio.bouza@gmail.com.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia +

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May 23, 2024

View abstract on PubMed

Summary

Implantable medical devices (IMDs) improve quality of life but face complications like infection and loosening. Future research focuses on advanced materials, AI, and novel therapies to enhance IMD safety and efficacy.

Area Of Science

Biomaterials Science
Medical Device Engineering
Regenerative Medicine

Background

Implantable medical devices (IMDs) are crucial for replacing body structures, significantly impacting patient quality of life and survival.
While many IMDs function for over 10-15 years, complications such as loosening, intolerance, and infection pose significant risks, increasing morbidity and healthcare costs.

Purpose Of The Study

To review the current landscape of implantable medical devices (IMDs), their materials, durability, and complications.
To highlight the challenges and future directions in IMD research and development, particularly concerning complications and scientific output in Spain.

Main Methods

Expert discussion and testimony on prostheses and implantable medical devices (IMDs).
Review of existing literature and challenges in IMD material science, biocompatibility, and complication management.
Analysis of the current state of scientific production in the field of IMDs.

Main Results

The majority of IMDs demonstrate long-term functionality, but non-infectious and infectious complications remain a significant concern.
Current strategies to combat IMD complications involve developing wear- and infection-resistant materials and utilizing antimicrobial substances.
Spain's scientific contribution to IMD research is estimated at less than 2% of the global total, indicating a need for increased investment and collaboration.

Conclusions

The future of IMDs hinges on advancements in materials, Artificial Intelligence for design, tissue regeneration, infection prevention, and alternative therapies like phage therapy.
Addressing IMD complications requires a multidisciplinary approach and greater commitment from industry and health authorities.
Enhancing Spain's role in IMD innovation is crucial for improving patient outcomes and aligning with socio-economic development.

Keywords:

Implantable Medical Devices Prostheses arthroplasties biomaterials cost design endocarditis endovascular devices health care expenditure. infection loosening materials scientific production