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Ultradynamic Isoreticularly Expanded Porous Organic Crystals.

Yunjia Zhang1, Rongran Liang1, Benjamin A Atterberry2,3

  • 1Department of Chemistry, Dartmouth College, 41 College Street, Hanover, New Hampshire 03755, United States.

Journal of the American Chemical Society
|May 23, 2024
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This summary is machine-generated.

Researchers developed new porous organic frameworks (HCOFs) that dramatically expand in size when exposed to solvents. This allows for the capture of large molecules, advancing targeted delivery applications.

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry
  • Nanotechnology

Background:

  • Porous organic materials with dynamic frameworks offer advanced adsorption and separation capabilities.
  • Porous hydrogen-bonded crosslinked organic frameworks (HCOFs) exhibit guest-responsive size changes but have limited void spaces.
  • Existing HCOFs have restricted framework dynamics due to limited void sizes.

Purpose of the Study:

  • To synthesize HCOFs with unprecedented solvent-induced size expansion capabilities.
  • To overcome the limitations of void size in HCOFs for enhanced framework dynamics.
  • To explore the potential of these dynamic frameworks for encapsulating large guest molecules.

Main Methods:

  • Isoreticular co-crystallization of complementary hydrogen-bonding building blocks.
  • Thiol-ene/yne single-crystal-to-single-crystal transformations for crosslinking.
  • Solvent-induced expansion and methanol-induced contraction experiments.

Main Results:

  • Synthesized HCOFs with enhanced chemical durability, high crystallinity, and extraordinary framework dynamics.
  • HCOF-104 crystals expanded up to 300% in DMF within 1 minute.
  • Demonstrated adsorption of guests larger than crystalline pore sizes, followed by encapsulation via contraction.

Conclusions:

  • Developed HCOFs with significant, solvent-triggered size expansion, overcoming previous void limitations.
  • These dynamic frameworks enable the capture and encapsulation of large guest molecules.
  • Presents new avenues for guest encapsulation and targeted delivery applications.