Related Experiment Videos
Evaluation of immune function in mice exposed to Ordram
Toxicology
|December 1, 1985
Summary
The thiocarbamate herbicide Ordram showed no significant impact on key immune system parameters in mice after acute exposure. This study suggests Ordram is unlikely to cause immunosuppression under the tested conditions.
Area of Science:
- Immunotoxicology
- Environmental Health
- Pesticide Safety
Background:
- Thiocarbamate herbicides are widely used in agriculture.
- Understanding pesticide effects on the immune system is crucial for public health.
- Ordram is a thiocarbamate herbicide with limited data on immunotoxicity.
Purpose of the Study:
- To evaluate the potential immunotoxic effects of the herbicide Ordram in mice.
- To assess Ordram's impact on various immune system parameters following acute oral exposure.
Main Methods:
- Mice were administered Ordram (20-320 mg/kg/day) via oral gavage for 12 days.
- Assessed immune parameters included organ weights, natural killer (NK) cell activity, lymphocyte proliferation, delayed-type hypersensitivity, and antibody responses.
- Cyclophosphamide was used as a positive control for immunosuppression.
Main Results:
- Ordram exposure did not result in consistent, significant alterations in the measured immune parameters.
- No adverse effects on body weight, lymphoid organ weights, NK cell activity, or lymphocyte responses were observed.
- Delayed-type hypersensitivity and antibody production against sheep red blood cells (SRBC) remained unaffected.
Conclusions:
- Ordram does not appear to significantly affect key immune system functions in mice following acute oral exposure.
- The findings suggest a low risk of immunotoxicity from Ordram under the experimental conditions.
- Further research may explore chronic exposure effects and different exposure routes.