Related Experiment Video

Updated: May 4, 2026

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
09:05

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Published on: May 4, 2015

27.7K

Deciphering the Enigma of Intramyocardial Hemorrhage Following Reperfusion Therapy in Acute ST-Segment Elevation

Yong Xin Yang1,2, Fei Zhou1,2,3, Te Wen1,2

  • 1From the Department of Cardiology, Yichang Central People's Hospital/The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, Hubei, China.

Cardiology in Review
|May 23, 2024
PubMed

Insights

Intramyocardial hemorrhage (IMH) contributes to the no-reflow phenomenon after ST-segment elevation myocardial infarction (STEMI). Understanding IMH mechanisms and treatments is key to improving outcomes for STEMI patients.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology

Background:

  • ST-segment elevation myocardial infarction (STEMI) requires reperfusion therapies like percutaneous coronary intervention.
  • The no-reflow phenomenon, linked to microvascular dysfunction, complicates STEMI treatment.
  • Intramyocardial hemorrhage (IMH) is increasingly recognized as a factor in no-reflow post-STEMI.

Purpose of the Study:

  • To explore the relationship between IMH and the no-reflow phenomenon in STEMI.
  • To review IMH mechanisms, diagnostics, predictors, and clinical implications.
  • To discuss current and future strategies for preventing and treating IMH in STEMI.

Main Methods:

  • Literature review focusing on intramyocardial hemorrhage and no-reflow in STEMI.
  • Analysis of diagnostic modalities for IMH detection.
  • Synthesis of data on predictive factors and clinical outcomes.
  • Examination of therapeutic and preventive strategies.

Main Results:

  • IMH is a significant contributor to the no-reflow phenomenon in STEMI.
  • Various diagnostic tools can identify IMH, with specific predictors identified.
  • IMH has notable clinical implications for STEMI patients.
  • Evolving strategies aim to mitigate IMH and improve reperfusion.

Conclusions:

  • A deeper understanding of IMH is crucial for managing STEMI patients.
  • Targeting IMH may offer novel therapeutic avenues.
  • Enhanced clinical outcomes for STEMI patients can be achieved through better IMH management.

Keywords:
acute ST-segment elevation myocardial infarctionintramyocardial hemorrhageno-reflow phenomenonreperfusion therapy

More Related Videos

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

4.6K
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

8.5K

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
2.1K
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
943
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
495
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
522
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54