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Automated Synthesis for the Safe Production of Organic Azides from Primary Amines
Tuo Jiang1, Guillaume Coin1,2, Samuele Bordi1
1Synple Chem AG, Kemptpark 18, 8310Kemptthal ,Switzerland.
Abstract:
Described herein is the development of an automated and reproducible process for the conversion of primary amines to organic azides utilizing prepacked capsules containing all the required reagents, including imidazole-1-sulfonyl azide tetrafluoroborate. Apart from manually loading the primary amine into the reaction vessel, the entire reaction and product isolation process can be achieved automatically, with no further user involvement, and delivers the desired organic azide in high purity. This practical and simple automated capsule-based method offers a convenient and safe way of generating organic azides without handling or exposure of potentially explosive reagents.
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