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Updated: Jun 25, 2025

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
Published on: February 3, 2023
Evolutionary Structure Conservation and Covariance Scores
Florian Eggenhofer1, Christian Höner Zu Siederdissen2,3,4
1Bioinformatics Group, Department of Computer Science University of Freiburg, Freiburg, Germany.
Abstract:
Effective homology search for non-coding RNAs is frequently not possible via sequence similarity alone. Current methods leverage evolutionary information like structure conservation or covariance scores to identify homologs in organisms that are phylogenetically more distant. In this chapter, we introduce the theoretical background of evolutionary structure conservation and covariance score, and we show hands-on how current methods in the field are applied on example datasets.
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