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Updated: Jun 25, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis

Min Xu1,2,3,4,5, Hai-Xia Wang1,2,3,4, Ping Zu1,2,3,4

  • 1Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.

Current Hypertension Reports
|May 23, 2024
PubMed

Insights

Exposure to preeclampsia during pregnancy increases offspring

Area of Science:

  • Obstetrics and Gynecology
  • Pediatrics
  • Cardiovascular Health

Background:

  • Preeclampsia is a severe pregnancy complication.
  • Preeclampsia is linked to increased hypertension risk in offspring.
  • The overall impact of in-utero preeclampsia exposure on offspring blood pressure is not fully understood.

Approach:

  • A systematic review and meta-analysis was conducted.
  • 23 studies were included from an initial pool of 2550 publications.
  • The study systematically assessed the effects of maternal preeclampsia on offspring blood pressure.

Key Points:

  • Offspring exposed to preeclampsia in utero had higher systolic blood pressure (SBP) by 2.0 mm Hg and diastolic blood pressure (DBP) by 1.4 mm Hg.
  • These findings were consistent across stratified analyses including sex, age, and gestational age.
  • Offspring of mothers with preeclampsia face an elevated risk of high blood pressure throughout childhood and young adulthood.

Conclusions:

  • Maternal preeclampsia exposure is associated with increased offspring blood pressure.
  • Monitoring blood pressure in offspring exposed to preeclampsia is crucial.
  • This research highlights a significant long-term cardiovascular health implication of preeclampsia.
Abstract

Keywords:
AgesAreasBlood pressureGestational ageMeta-analysisOffspringPreeclampsiaSexesSystematic review

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