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Predictive value of the HALP score for pre-eclampsia with severe features
Zekiye Soykan Sert1, Mete Bertizlioğlu2
1Department of Gynecology and Obstetrics, Aksaray University Medical School, Aksaray, Turkey.
Postgraduate Medicine
|May 23, 2024
Summary
The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score can predict severe pre-eclampsia. A higher HALP score in early pregnancy indicates a greater risk of developing severe pre-eclampsia.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Clinical Diagnostics
Background:
- Pre-eclampsia poses significant risks during pregnancy, necessitating reliable predictive tests.
- Early identification of severe pre-eclampsia is crucial for maternal and fetal outcomes.
Purpose of the Study:
- To evaluate the predictive capability of the Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score for pre-eclampsia severity.
- To assess the HALP score as an independent predictor of severe pre-eclampsia features.
Main Methods:
- Retrospective analysis of data from 229 pre-eclampsia patients and 142 healthy controls (January 2019-January 2023).
- Calculation of the HALP score using first-trimester blood parameters.
- Comparison of HALP scores between pre-eclampsia groups (severe vs. non-severe features) and controls.
Main Results:
- The HALP score was significantly higher in pre-eclampsia patients with severe features compared to controls (6.18 ± 2.66 vs. 3.75 ± 1.86, p=0.006).
- The HALP score independently predicted severe pre-eclampsia (OR: 2.02, 95% CI: 1.10-3.32, p=0.017).
- A HALP score > 4.61 demonstrated 74.5% sensitivity and 81.3% specificity for predicting severe pre-eclampsia.
Conclusions:
- A significant correlation exists between the HALP score and the presence of severe pre-eclampsia features.
- The HALP score shows potential as a valuable tool for predicting pre-eclampsia severity in early pregnancy.
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