Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.2K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.2K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

4.5K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.5K
The Cell Cycle Control System01:28

The Cell Cycle Control System

2.8K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
2.8K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

2.5K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
2.5K
Positive Regulator Molecules01:45

Positive Regulator Molecules

106.0K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
106.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural Biosignatures-A Category of Potential Biosignatures in the Life Detection Knowledge Base.

Astrobiology·2025
Same author

Introduction to the Life Detection Knowledge Base Project.

Astrobiology·2025
See all related articles

Related Experiment Video

Updated: Jun 25, 2025

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.6K

Self-Organization and Phase Transitions in Driven Cellular Automata.

J Hank Rainwater1

  • 1Retired Electromagnetic Sciences, Engineering Experiment Station (now the Georgia Tech Research Institute). rainwater.hank@gmail.com.

Artificial Life
|May 23, 2024
PubMed
Summary

This study modifies the Game of Life (GoL) cellular automaton to create ordered structures by permanently activating stable patterns. This artificial chemistry approach mimics natural self-organization, leading to predictable structure formation and insights into prebiotic chemistry.

Keywords:
Game of Lifecellular automataprebiotic origins of lifeselective self-assemblyself-organization

More Related Videos

Forming, Confining, and Observing Microtubule-Based Active Nematics
08:37

Forming, Confining, and Observing Microtubule-Based Active Nematics

Published on: January 13, 2023

2.6K
Cell Co-culture Patterning Using Aqueous Two-phase Systems
10:11

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Published on: March 26, 2013

18.4K

Related Experiment Videos

Last Updated: Jun 25, 2025

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging
09:56

Mapping the Emergent Spatial Organization of Mammalian Cells using Micropatterns and Quantitative Imaging

Published on: April 30, 2019

6.6K
Forming, Confining, and Observing Microtubule-Based Active Nematics
08:37

Forming, Confining, and Observing Microtubule-Based Active Nematics

Published on: January 13, 2023

2.6K
Cell Co-culture Patterning Using Aqueous Two-phase Systems
10:11

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Published on: March 26, 2013

18.4K

Area of Science:

  • Artificial chemistry
  • Complex systems
  • Cellular automata

Background:

  • The Game of Life (GoL) is a cellular automaton with complex emergent behavior.
  • Understanding self-organization in artificial systems can provide insights into natural processes.

Purpose of the Study:

  • To modify the GoL to inject order during state transitions.
  • To investigate the phenomenology and dynamics of the modified GoL.
  • To explore the GoL as a model for artificial chemistry and self-organization.

Main Methods:

  • Modification of the GoL state transition algorithm.
  • Permanent activation of selected stable structures (still lifes).
  • Analysis of emergent structures and phase transitions.

Main Results:

  • Novel structures are created through the interaction of permanent seeds and random active sites.
  • The modified GoL exhibits phase transitions with selective self-assembly.
  • Geometrically identical structures emerge from identical seeds, leading to a static density equilibrium.

Conclusions:

  • The modified GoL demonstrates a form of artificial chemistry capable of ordered structure formation.
  • This model provides an analogy for natural self-organization, from geochemistry to prebiotic chemistry.
  • Permanently active seeds can guide emergent complexity and self-assembly in cellular automata.