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Immunotherapy in Sarcoma: Current Data and Promising Strategies.
Georgina E Wood1, Christian Meyer2, Florent Petitprez3
1University College Hospital of London, London, United Kingdom.
Summary
Sarcomas, once thought immune-silent, show potential for immunotherapy. Some bone and soft tissue sarcomas are
Area of Science:
- Oncology and Immunology
Background:
- Sarcomas traditionally exhibit low tumor mutational burden (TMB) and an immunosuppressive tumor microenvironment (TME).
- However, a subset of sarcomas are immunologically 'hot,' with high TMB, PD-L1 expression, CD8+ T cells, or tertiary lymphoid structures (TLS).
- These 'hot' sarcomas demonstrate sensitivity to immunotherapy.
Purpose of the Study:
- To review current evidence on immunotherapy for bone sarcomas (BS) and soft tissue sarcomas (STS).
- To explore various immunotherapy modalities and biomarkers of response.
Main Methods:
- Review of existing research on immunotherapy in bone and soft tissue sarcomas.
- Analysis of immune checkpoint inhibitors (ICI) and adoptive cellular therapies.
- Examination of chimeric antigen receptor (CAR) T-cell therapies, tumor-infiltrating lymphocytes (TILs), and cancer vaccines.
Main Results:
- Evidence suggests certain sarcomas are responsive to immunotherapy.
- Immune checkpoint inhibitors (ICI) and adoptive cellular therapies show promise.
- Biomarkers are crucial for predicting response to these treatments.
Conclusions:
- Immunotherapy represents a growing area of treatment for specific sarcoma subtypes.
- Further research into biomarkers and novel therapeutic strategies is warranted.
- Targeting the immune microenvironment holds potential for improving sarcoma outcomes.
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