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Postmenopausal Bleeding After Coronavirus Disease 2019 (COVID-19) Vaccination: Vaccine Adverse Event Reporting System

Penelope Strid1, Winston E Abara, Elizabeth Clark

  • 1COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.

Obstetrics and Gynecology
|May 23, 2024
PubMed

Insights

Postmenopausal bleeding events reported after COVID-19 vaccination are rare. Verified cases were infrequent, with causes aligning with known postmenopausal bleeding factors, indicating no new safety concerns.

Area of Science:

  • Vaccinology
  • Gynecology
  • Public Health

Background:

  • The Vaccine Adverse Event Reporting System (VAERS) monitors vaccine safety in the U.S.
  • Postmenopausal bleeding (PMB) is a gynecological concern in women over 50.
  • Understanding potential adverse events following COVID-19 vaccination is crucial.

Purpose of the Study:

  • To investigate the occurrence of postmenopausal bleeding reports following COVID-19 vaccination.
  • To assess the frequency and characteristics of these reported events.

Main Methods:

  • Retrospective analysis of U.S. VAERS data from December 13, 2020, to December 13, 2021.
  • Identification and verification of postmenopausal bleeding reports among COVID-19 vaccine recipients.
  • Calculation of event rates per 1 million vaccinated women aged 50+.

Main Results:

  • 554 presumptive PMB reports identified among 711,224 COVID-19 vaccination reports.
  • 434 reports were verified, with an estimated rate of 7 verified PMB reports per 1 million vaccinated women (aged 50+).
  • Causes of verified PMB were consistent with established etiological factors.

Conclusions:

  • Postmenopausal bleeding following COVID-19 vaccination is a rare event.
  • The incidence and reported causes do not suggest a novel association.
  • Findings support the established safety profile of COVID-19 vaccines regarding PMB.

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