[Delayed hypersensitivity reaction to rat xenoantigens in mice]

A scheme of delayed-type hypersensitivity (DTH) to xenogeneic lymphoid cells induced in mice was suggested. Subcutaneous injection of normal mice with 5 X 10(6) rat spleen cells in a complete Freund's adjuvant with the results evaluated 5 days after was found the optimal condition for DTH development. Mediated by T lymphocytes the response was shown to be maximal 24 hours after the challenge.