Related Experiment Video
Updated: Jun 25, 2025
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Perioperative Evaluation and Management of Children with Osteoporosis and Low Bone Mineral Density
Jordan D Ross1, Alicia Diaz-Thomas2
1University of Tennessee Health Science Center, Faculty Office Building, Room 119, 49 North Dunlap, Memphis, TN 38103, USA.
Insights
Optimizing bone health in pediatric osteoporosis requires a multidisciplinary approach. Bisphosphonate therapy, physical therapy, and vitamin D are key for bone accrual and surgical success.
Area of Science:
- Pediatric Endocrinology
- Pediatric Orthopedics
- Pediatric Bone Health
Background:
- Medical and surgical options for pediatric osteoporosis are expanding.
- Multidisciplinary strategies are crucial for optimizing bone health in children.
- Individualized interpretation of bone mineral density and fracture history is essential.
Purpose of the Study:
- To highlight the importance of multidisciplinary strategies in pediatric osteoporosis.
- To discuss the role of bisphosphonate therapy in bone accrual and perioperative management.
- To emphasize adjunctive therapies for optimal surgical outcomes in pediatric patients.
Main Methods:
- Review of current medical and surgical treatment options for pediatric osteoporosis.
- Analysis of the role and safety of bisphosphonate therapy in children.
- Evaluation of adjunctive interventions like physical therapy and vitamin D supplementation.
Main Results:
- Off-label bisphosphonate use is a standard pharmacologic intervention for bone accrual in pediatric osteoporosis.
- Bisphosphonate therapy can be continued perioperatively in select cases.
- Rare side effects like osteonecrosis of the jaw and atypical femur fractures appear less frequent in children.
Conclusions:
- A multidisciplinary approach is vital for managing pediatric osteoporosis.
- Bisphosphonates are a key component of therapy, with potential for perioperative continuation.
- Physical therapy and vitamin D supplementation are important for surgical success and overall bone health.
Abstract:
As medical and surgical treatment options for children with osteoporosis expand, multidisciplinary strategies for bone health optimization become more important. Each patient's bone mineral density and fracture history should be interpreted in context. Off-label bisphosphonate use is a standard pharmacologic intervention for children with osteoporosis for optimal bone accrual. It is possible to continue this therapy perioperatively under certain circumstances. The rare side effects (osteonecrosis of the jaw and atypical femur fractures) seem less common in children. Physical therapy, vitamin D supplementation, and other interventions are also important tools for optimal bone health perioperatively and for satisfactory surgical outcomes.
More Related Videos
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
07:11Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
Published on: February 5, 2019
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Osteoclasts in Bone Remodeling
01:40Bone Remodeling
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:31Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...