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Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
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Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

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Updated: May 7, 2026

Anterior Cervical Discectomy and Fusion in the Ovine Model
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Four-Level Cervical Disc Arthroplasty.

Hsuan-Kan Chang1,2,3, Chih-Chang Chang1,2, Tsung-Hsi Tu1,2

  • 1Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

International Journal of Spine Surgery
|May 23, 2024
PubMed
Summary
This summary is machine-generated.

Four-level cervical disc arthroplasty (CDA) offers a safe and effective surgical option for select patients, improving clinical outcomes and preserving motion. This procedure is particularly suitable for individuals with mild cervical spondylosis and disc herniations.

Keywords:
anterior cervical discectomy and fusion (ACDF)cervical disc arthroplasty (CDA)four-levelmulti-levelrange of motion (ROM)

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Area of Science:

  • Neurosurgery
  • Orthopedic Surgery
  • Spine Surgery

Background:

  • Multilevel anterior cervical discectomy and fusion (ACDF) carries higher risks of pseudarthrosis and reoperation compared to single-level procedures.
  • Cervical disc arthroplasty (CDA) offers a motion-preserving alternative for multilevel cervical spondylosis.
  • Four-level CDA is a less common but potentially valuable surgical option.

Purpose of the Study:

  • To evaluate the clinical and radiological outcomes of four-level cervical disc arthroplasty (CDA).
  • To assess the safety and efficacy of four-level CDA in a highly selected patient group.

Main Methods:

  • Retrospective review of consecutive patients undergoing four-level CDA.
  • Inclusion criteria: medically refractory symptomatic cervical spondylotic myelopathy/radiculopathy with multilevel disc herniations and mild spondylosis.
  • Assessment of clinical outcomes, global/segmental range of motion (ROM) at C3-7, and complications.

Main Results:

  • Twenty patients (mean age 56) with a mean follow-up of 34 months showed improved clinical outcomes post-surgery.
  • Global and segmental ROM at C3-7 were preserved and trended towards an increase (35° to 37°).
  • One case of permanent C5 radiculopathy occurred; no other neurological issues or reoperations were reported.

Conclusions:

  • Four-level CDA is a safe and effective procedure for specific indications, yielding clinical improvement and preserving segmental motion.
  • This surgery is well-suited for patients with multilevel disc herniations and mild cervical spondylosis.
  • Low complication rates support four-level CDA as a viable option for carefully selected patients.