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Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Biomarkers In Cancer Screening: Promises And Challenges In Cancer Early Detection.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Biomarkers In Cancer Screening: Promises And Challenges In Cancer Early Detection.

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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

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Published on: October 26, 2017

Biomarkers in Cancer Screening: Promises and Challenges in Cancer Early Detection.

Indu Kohaar¹, Nicholas A Hodges¹, Sudhir Srivastava¹

¹Cancer Biomarkers Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, 9609 Medical Center Drive, NCI Shady Grove Building, Rockville, MD 20850, USA.

Hematology/Oncology Clinics of North America

|May 23, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Early cancer detection is crucial for effective treatment but is hindered by a lack of screening methods. New molecular tools like liquid biopsies offer promising avenues for earlier cancer diagnosis.

Keywords:

Biomarkers Early detection Precancer Screening

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Area of Science:

Oncology
Molecular Diagnostics
Medical Imaging

Background:

Cancer remains a leading global cause of death, often due to late-stage diagnosis.
Effective cancer intervention is significantly improved by early detection.
Most cancers lack validated screening tests for early, asymptomatic detection.

Purpose of the Study:

To highlight the critical need for advanced screening and detection tools for aggressive cancers.
To explore novel molecular and imaging approaches for early cancer diagnosis.

Main Methods:

Review of current limitations in cancer screening procedures.
Discussion of emerging molecular cancer screening techniques.
Integration of molecular assays with imaging for enhanced detection.

Main Results:

Germline testing, synthetic biomarkers, and liquid biopsy are key developments.
These methods aim to improve the precision of early cancer detection.
Combining molecular tools with imaging offers a path forward.

Conclusions:

There is a significant unmet need for early cancer detection strategies.
Molecular screening tools and advanced imaging are vital for improving patient outcomes.
Further development and validation of these approaches are essential for combating cancer mortality.