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A case-control study of the risk factors for fistula-in-ano in infants and toddlers
Yanting Sun1,2, Hongtao Liang3, Shuang Hao1
1Department of Anorectal Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Insights
Fistula-in-ano (FIA) in infants and toddlers is linked to maternal delivery history and infant’s bowel habits. Frequent loose stools and using wipes for cleaning are significant risk factors for developing FIA.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Neonatology
Background:
- Fistula-in-ano (FIA) in infants and toddlers is under-researched, impacting child well-being.
- Identifying risk factors is crucial for early intervention and management.
Purpose of the Study:
- To pinpoint risk factors for FIA in young children.
- To inform preventive strategies and therapeutic approaches for FIA.
Main Methods:
- Retrospective case-control study (41 FIA cases vs. 41 controls).
- Data collected on maternal, perinatal, infant feeding/defecation, and family dietary factors.
- Logistic regression analysis identified significant risk factors.
Main Results:
- Mothers of FIA infants had more previous deliveries.
- Infants with FIA showed less mealtime, higher exclusive breastfeeding, frequent loose stools, and greater wipe use.
- Key risk factors: maternal delivery history (OR 6.327), stool frequency (OR 5.351), stool consistency (OR 5.017), and wipe use (OR 8.089).
Conclusions:
- FIA in infants and toddlers is associated with maternal parity, stool irregularities, and perianal hygiene practices.
- Improving stool consistency and appropriate perianal care are vital for prevention.
- Further validation in diverse settings is recommended.
Background:
Limited data are available regarding the risk factors for fistula-in-ano (FIA) in infants and toddlers, potentially affecting their daily lives.
Objectives:
The purpose of this study was to identify potential risk factors for FIA in infants and toddlers, in order to implement early preventive interventions, avoid disease progression, and develop therapeutic strategies.
Design And Settings:
A retrospective case-control study was conducted, comparing 41 infants and toddlers diagnosed with FIA with 41 healthy controls, between August 2020 and December 2021.
Independent Variables:
(a) maternal characteristics during pregnancy and delivery, (b) perinatal characteristics, dietary behaviors, and defecation-related behaviors in infants and toddlers, (c) family dietary behaviors.
Results:
Mothers of infants and toddlers with FIA had given birth more times in the past, while the infants and toddlers themselves had less mealtime, a higher rate of exclusive breastfeeding, frequent loose stools, and a larger proportion of used wipes, experiencing perianal skin anomalies. The logistic regression analysis revealed that there are four significant risk factors associated with the development of FIA in infants and toddlers, including the number of previous deliveries by the mother (OR 6.327), defecation frequency score (OR 5.351), stool consistency score (OR 5.017), and cleaning with wipes after defecation (OR 8.089).
Conclusion:
Based on our data, it appeared that FIA in infants and toddlers could be attributed to several factors. These included an increased number of previous deliveries by mothers, frequent loose stools, and repeated wipe use. To prevent the occurrence and worsening of the disease, it is important to improve the frequency and consistency of stooling and provide proper care. Further research is required to verify these findings in other clinical settings.
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